10 Feb 2017 --- Scientists from the University of Rochester Medical Center have discovered that omega 3 fatty acids contained in fish oil could be used to treat patients suffering from asthma.

People with asthma have an imbalance between molecules that dampen inflammation and those that increase inflammation. Using steroids as treatment controls the inflammation and relieves symptoms, but does not cure the underlying disease.

Researchers found that, by using cell cultures from local asthma patients, Omega-3 fatty acid products can reduce the production of IgE, the antibodies that cause allergic reactions and asthma symptoms in people with milder cases of asthma.

However, the study also found that in patients with severe asthma who use high doses of oral steroids, the omega-3 fatty acids are less effective because the corticosteroids block the beneficial effects.

The same researchers previously showed that certain fatty acids contained in fish oil regulate the function of immune cells (B cells). This lead them to further investigate the effects on asthma.

Lead author, Richard P. Phipps, Ph.D., and his team, collected blood from 17 patients at UR Medicine's Mary Parkes Asthma Center and isolated their B immune cells in the laboratory to explore the impact of pure omega-3-derived products on IgE and other molecules that fuel the disease.

Co-authors conducted much of the laboratory and clinical work, and compared the results of the 17 patients to donors of healthy blood cells.

Most of the patients who volunteered for the study were taking corticosteroids in either pill form or by inhaler, depending upon severity of their asthma.

The results showed that all responded to the omega-3 fatty acids to some degree, as evidenced by a reduction in the levels of IgE antibodies.

However, unexpectedly, Phipps said, the cells from a small subset of patients who were taking oral steroids were less sensitive to the omega-3 treatment.

Steroids are usually a very effective treatment for asthma. However, although the science is in the early stages, it appears that when corticosteroids are used steadily, in some cases the steroids reduce some of the body's natural ability to fight asthma-related inflammation, Phipps said.

The URMC discovery coincides with a New England Journal of Medicine study in late December 2016, showing that prenatal exposure to fish oil reduced the risk of wheeze and asthma in children.

Phipps noted that the fish oil used as a dietary supplement in the NEJM study was a special high-quality preparation--and that consumers should use caution when buying fish oil because not all fish oil is the same.

“You really need high-quality, standardized material that's been processed and stored correctly before comparing results from one study to another study,” Phipps said.

“Our study used the pure, biologically active products in fish oil, known as 17-HDHA, and we've provided a clear line of evidence for why intake of high-quality fish oil is good.”


Source: Nutrition Horizon