Leiden, The Netherlands, February 18, 2010. Biotech company Pharming Group NV (“Pharming” or “the Company”) (NYSE Euronext: PHARM) announced today its preliminary results for the year ended December 31, 2009.

Key financial developments
€20.0 million Standby Equity Distribution Agreement (“SEDA”) signed with YA Global Master SPV LTD (“YA Global”) in April 2009, plus a €10.0 million extension in October 2009. Total financing under the SEDA received in 2009 of €6.6 million, with another €23.4 million available to date;

€70.0 million convertible bonds (issued in 2007) reduced to €10.9 million at December 31, 2009 from €49.9 million at year end 2008;

Decrease of operational costs from €30.1 million in 2008 to €28.9 million in 2009 as a result of €4.0 million lower non-cash impairment charges (€4.2 million in 2008; €0.2 million in 2009), which was offset with a €2.4 million increase of research and development costs driven by the submission of the EU Marketing Authorization Application for Rhucin® in September 2009, intensified efforts for the Rhucin program in North America and the clinical development of Prodarsan®;

Net loss in 2009 of €32.1 million as compared to €26.2 million in 2008 primarily caused by the effect of a non-cash derivative profit of €4.9 million in 2008 and €1.6 million lower net interest income on cash and marketable securities.

“2009 was a challenging year for Pharming in which we have made significant progress on a number of fronts, for example by clearing the vast majority of our convertible debt and in creating a decent financial platform through a SEDA with YA Global and a short-term convertible debt financing of €7.5 million (secured just after year end 2009) from which we are confident we can continue to bring Rhucin through a successful regulatory review process,” said Dr. Sijmen de Vries, Chief Executive Officer of Pharming. “2010 is set to be a transformational year for Pharming as we remain confident in securing European approval for Rhucin and remain on track for BLA filing in the USA. We are also in discussions with a number of parties for commercialisation of Rhucin rights in major world markets and we anticipate the conclusion of commercial partnerships and additional financing in the first half of this year.”

Outlook 2010
Opinion on Marketing Authorization Application for Rhucin from the European Medicines Agency in HY2

Clarity on the filing and review process for Rhucin in the USA for the treatment of acute attacks of Hereditary Angioedema in HY1

Initiation clinical development of rhC1INH for applications in the field of transplant indications in 2010

Start clinical Phase II/III studies with Prodarsan in Cockayne Syndrome patients expected end of 2010

Commercialisation agreement(s) for Rhucin in HY1 2010.

Further improvement of the financial position by (combinations of) project-specific financing, licensing deals, loans and equity transactions