01 Feb 2018 --- The potential health benefits of dietary fat sources such as olive and fish oil have attracted a lot of scientific and consumer interest over the past years. A study led by the University of Granada (UGR), however, has now indicated that the long-term intake of sunflower or fish oils may damage the liver, giving rise to non-alcoholic steatohepatitis (NASH). Three dietary fats (virgin olive oil, sunflower oil and fish oils) were studied, and virgin olive oil was found to be best of the three for preserving the liver throughout life, the researchers say.

NASH is a serious condition which causes inflammation of the liver that is not caused by alcohol abuse and can act as a catalyst for the onset of other diseases such as cirrhosis and liver cancer. The prevalence of NASH in the general population increases with age, affecting 1 percent to 3 percent of children, 5 percent of teenagers, 18 percent of those aged between 20 and 40, 39 percent of those aged between 40 and 50, and more than 40 percent of those over 70.

The research, recently published in the Journal of Nutritional Biochemistry, analyzed how the long-term consumption of different dietary fat sources such as olive, sunflower and fish oil affects the liver of rats. UGR researchers conducted a series of comprehensive analyses, including studies of pathological anatomy, ultrastructural analyses using electron microscopes, sophisticated bioenergy techniques, telomere length measurements and oxidative stress. Most importantly, they conducted a comprehensive study of the liver genome to establish how it evolved in line with the consumption of the different oils.

Three dietary fats (virgin olive oil, sunflower oil and fish oils) were studied, and virgin olive oil was shown to be best of the three for preserving the liver throughout life. The research also revealed that sunflower oil induced fibrosis, ultrastructural alterations, gene expression blockades and high oxidation. Meanwhile, fish oil intensified oxidation associated with aging, lowered mitochondrial electron transport chain activity and altered the relative telomere length. Telomeres are the ends of chromosomes, the shortening of which can cause cell aging and the lengthening of which can cause cancer.

As José Luis Quiles Morales, Full Professor of Physiology at the UGR explains: “[the research] demonstrates that fat accumulates in the liver with age, but the most striking finding is that the type of fat accumulated differs depending on the oils consumed and this means that, regardless of this accumulation, some livers age in a healthier way than others and with a greater or lesser predisposition to certain diseases.”

“The alterations caused by the long-term consumption of sunflower and fish oils make the liver susceptible to non-alcoholic steatohepatitis, a very serious disease that may act as a catalyst for other liver diseases such as cirrhosis and liver cancer,” Professor Quiles notes, adding that: “virgin olive oil is the healthiest option, which has already been proven in relation to diverse aspects of health.”

According to Professor Quiles, the most innovative aspect of this study is “how it reveals the mechanisms by which virgin olive oil provides these benefits and why the over-consumption of other dietary fats is dangerous. We believe that this study will be very useful in preventing and treating diverse liver diseases.”

Researchers from other institutions, such as the Hospital Complex of Jaen, the Marche Polytechnic University (UNIVPM) in Ancona, Italy, the Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research (GENYO) and the National Cancer Institute (NCI) of the US, have also participated in this research project.