Midnight snacking could make sunbathing more dangerous, says study

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Algemeen advies 16/08/2017 12:57
16 Aug 2017 --- Eating a midnight snack might make sunbathing the next day more dangerous, according to new research. A study in mice from the O'Donnell Brain Institute and University of California (UC) Irvine in the US shows that eating at abnormal times disrupts the biological clock of the skin, including the effectiveness during the daytime of an enzyme that protects against the sun's harmful ultraviolet (UV) radiation.

Although further research is needed, the result indicates that people who eat late at night may be more vulnerable to sunburn and longer-term effects such as skin aging and skin cancer, according to Dr. Joseph S. Takahashi, Chairman of Neuroscience at UT Southwestern Medical Center's Peter O'Donnell Jr. Brain Institute.

“This finding is surprising. I did not think the skin was paying attention to when we are eating,” says Dr. Takahashi.

The study’s results show that mice given food only during the day – an abnormal eating time for the otherwise nocturnal animals – sustained more skin damage when exposed to ultraviolet B (UVB) light during the day than during the night. This outcome is said to have occurred, at least in part, because an enzyme that repairs UV-damaged skin – xeroderma pigmentosum group A (XPA) – moved its daily cycle to be less active in the day.

Mice that fed only during their usual evening times did not show altered XPA cycles and were less susceptible to daytime UV rays.

“It is likely that if you have a normal eating schedule, then you will be better protected from UV during the daytime,” says Dr. Takahashi. “If you have an abnormal eating schedule, that could cause a harmful shift in your skin clock, like it did in the mouse.”

Feeding times’ role
Previous studies have shown that the body's circadian rhythms have strong roles in skin biology. However, prior to this study, little had been understood about what controls the skin's daily clock.

The latest research, published in Cell Reports, makes clear the vital role of feeding times, a factor that scientists focused on because it had already been known to affect the daily cycles of metabolic organs such as the liver.

The study found that besides disrupting XPA cycles, changing eating schedules could affect the expression of about 10 percent of the skin's genes.

Hard to translate
However, more research is needed to better understand the links between eating patterns and UV damage in people, particularly how XPA cycles are affected, says Dr. Bogi Andersen of UC Irvine, who led the collaborative study with Dr. Takahashi.

“It's hard to translate these findings to humans at this point,” says Dr. Andersen, Professor of Biological Chemistry. “But it's fascinating to me that the skin would be sensitive to the timing of food intake.”

To better understand the subject, Dr. Takahashi, known for his landmark discovery of the Clock gene regulating circadian rhythms, is also researching other ways in which eating schedules affect the biological clock, according to UC Irvine. A study earlier this year reinforced the idea that the time of day food is eaten is more critical to weight loss than the amount of calories ingested. He is now conducting long-term research measuring how feeding affects aging and longevity.

The UV study was supported by the Irving Weinstein Foundation, the National Institutes of Health, the China Scholarship Council, and the National Science Foundation Graduate Research Fellowship



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